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Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.628

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_-_95794416	2.589	NM_000439	PCSK1	proprotein convertase subtilisin/kexin type 1
chr18_-_56190980	1.983	NM_005912	MC4R	melanocortin 4 receptor
chr10_+_114033403	1.961	NM_058222	TECTB	tectorin beta
chr4_+_77575276	1.959	NM_020859	SHROOM3	shroom family member 3
chr7_+_89681069	1.911	NM_001040666	STEAP2	six transmembrane epithelial antigen of the prostate 2
chr10_-_73518772	1.823	NM_001134434 NM_014767	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_+_77212524	1.767	NM_032024	C10orf11	chromosome 10 open reading frame 11
chr12_-_10846435	1.716	NM_023919	TAS2R7	taste receptor, type 2, member 7
chr12_-_66839589	1.679	NM_000619	IFNG	interferon, gamma
chr7_+_29486010	1.676	NM_001039936	CHN2	chimerin (chimaerin) 2
chr1_-_150328153	1.657	NM_001008536	TCHHL1	trichohyalin-like 1
chr3_-_156904690	1.565	NM_014996	PLCH1	phospholipase C, eta 1
chr9_-_4142182	1.544	NM_152629	GLIS3	GLIS family zinc finger 3
chr4_+_185063421	1.519	NM_020225	STOX2	storkhead box 2
chr3_-_42280442	1.455	NM_001174138	CCK	cholecystokinin
chr1_-_155936904	1.352	NM_052939	FCRL3	Fc receptor-like 3
chr13_-_27441290	1.335	NM_001265	CDX2	caudal type homeobox 2
chr2_+_204509698	1.315	NM_012092	ICOS	inducible T-cell co-stimulator
chr17_-_25685175	1.274	NM_206832	TMIGD1	transmembrane and immunoglobulin domain containing 1
chr17_+_57811645	1.222	NM_173503	EFCAB3	EF-hand calcium binding domain 3
chr2_-_238813365	1.212	NM_001142853 NM_018645	HES6	hairy and enhancer of split 6 (Drosophila)
chr1_+_156842852	1.206	NM_001004478	OR10Z1	olfactory receptor, family 10, subfamily Z, member 1
chr3_+_157491469	1.205	NM_172159	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr4_+_114433551	1.196		ANK2	ankyrin 2, neuronal
chr9_-_21177529	1.175	NM_021068	IFNA4	interferon, alpha 4
chr13_-_27441143	1.169		CDX2	caudal type homeobox 2
chr9_+_21399132	1.162	NM_002170	IFNA8	interferon, alpha 8
chr6_-_101018271	1.148	NM_005068	SIM1	single-minded homolog 1 (Drosophila)
chr12_+_7755316	1.148	NM_199286	DPPA3 STELLAR	developmental pluripotency associated 3 developmental pluripotency associated 3 pseudogene
chr5_+_79366746	1.126	NM_003248	THBS4	thrombospondin 4
chr10_+_91127792	1.123	NM_001010987	IFIT1B	interferon-induced protein with tetratricopeptide repeats 1B
chr9_-_21340885	1.110	NM_021002	IFNA6	interferon, alpha 6
chr11_-_117552545	1.088	NM_004588	SCN2B	sodium channel, voltage-gated, type II, beta
chr11_+_123945102	1.071	NM_001005194	OR8A1	olfactory receptor, family 8, subfamily A, member 1
chr2_-_238813284	1.054		HES6	hairy and enhancer of split 6 (Drosophila)
chr3_+_45902999	1.047	NM_006641 NM_031200	CCR9	chemokine (C-C motif) receptor 9
chr7_+_142629251	1.045	NM_176882	TAS2R40	taste receptor, type 2, member 40
chr13_-_27441423	1.039		CDX2	caudal type homeobox 2
chr12_+_7833261	1.035	NM_024865	NANOG	Nanog homeobox
chr9_+_134843918	1.031	NM_001135031 NM_004188	GFI1B	growth factor independent 1B transcription repressor
chr9_-_21229975	1.004	NM_002172	IFNA14	interferon, alpha 14
chr5_+_140751666	0.997	NM_014004 NM_032088	PCDHGA8	protocadherin gamma subfamily A, 8
chr15_-_76313896	0.989	NM_015162	ACSBG1	acyl-CoA synthetase bubblegum family member 1
chr9_-_21197141	0.987	NM_002171	IFNA10	interferon, alpha 10
chr12_-_7547552	0.959	NM_004244 NM_203416	CD163	CD163 molecule
chr18_-_59462469	0.948	NM_002974	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr3_+_99484421	0.918	NM_001005482	OR5H2	olfactory receptor, family 5, subfamily H, member 2
chr10_-_74863303	0.910	NM_001024593	ZMYND17	zinc finger, MYND-type containing 17
chr13_+_108079570	0.907	NM_001198950	MYO16	myosin XVI
chr3_-_56784634	0.900	NM_001128616	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr8_-_93099040	0.889	NM_175636	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_+_135106578	0.875	NM_001159701 NM_001159699	FHL1	four and a half LIM domains 1
chr12_+_7833292	0.873		NANOG	Nanog homeobox
chr12_+_20854904	0.871	NM_019844	SLCO1B3	solute carrier organic anion transporter family, member 1B3
chr18_+_50646616	0.868	NM_004163	RAB27B	RAB27B, member RAS oncogene family
chr12_-_9123126	0.854		A2M	alpha-2-macroglobulin
chr3_+_63403792	0.853	NM_144642	SYNPR	synaptoporin
chr1_-_146492471	0.847	NM_015383	NBPF14 NBPF1	neuroblastoma breakpoint family, member 14 neuroblastoma breakpoint family, member 1
chr13_+_96592051	0.844		MBNL2	muscleblind-like 2 (Drosophila)
chr10_+_124141808	0.840	NM_021622	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chrX_+_135397790	0.840	NM_001727	BRS3	bombesin-like receptor 3
chr12_+_103221590	0.837	NM_001008394	EID3	EP300 interacting inhibitor of differentiation 3
chr9_-_21192201	0.822	NM_021057	IFNA7	interferon, alpha 7
chr4_-_21155376	0.809	NM_001035004	KCNIP4	Kv channel interacting protein 4
chr18_-_26876622	0.807	NM_001941 NM_024423	DSC3	desmocollin 3
chr7_+_37689903	0.807
chr10_-_69125932	0.804	NM_013266	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr4_-_123761615	0.778	NM_021803	IL21	interleukin 21
chrX_+_7147471	0.770	NM_000351	STS	steroid sulfatase (microsomal), isozyme S
chr4_+_154397975	0.765		TRIM2	tripartite motif containing 2
chr2_-_171631728	0.750	NM_001136555	TLK1	tousled-like kinase 1
chr12_-_69600514	0.738		PTPRR	protein tyrosine phosphatase, receptor type, R
chr4_-_41445479	0.725		PHOX2B	paired-like homeobox 2b
chr6_+_50894397	0.723	NM_003221	TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_+_190552744	0.721	NM_001039152	RGS21	regulator of G-protein signaling 21
chr9_+_6205804	0.715		IL33	interleukin 33
chr11_-_128242342	0.712	NM_153764 NM_153765 NM_153766 NM_153767	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1
chr5_+_140719773	0.709	NM_018923 NM_032096	PCDHGB2	protocadherin gamma subfamily B, 2
chr8_-_26780645	0.700
chr2_-_215998181	0.696		FN1	fibronectin 1
chr16_+_74868676	0.696	NM_033401	CNTNAP4	contactin associated protein-like 4
chr13_+_22653059	0.694	NM_000231	SGCG	sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr6_-_76838944	0.693	NM_001563	IMPG1	interphotoreceptor matrix proteoglycan 1
chr16_+_70646008	0.686	NM_001126102 NM_005143	HP	haptoglobin
chr1_+_116181927	0.685		NHLH2	nescient helix loop helix 2
chrX_-_55037235	0.682	NM_002625	PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr3_+_109504021	0.681	NM_007072	HHLA2	HERV-H LTR-associating 2
chrX_-_15312390	0.673	NM_004469	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)
chr5_-_135318420	0.668	NM_002302	LECT2	leukocyte cell-derived chemotaxin 2
chr3_+_99555387	0.660	NM_001005517	OR5K4	olfactory receptor, family 5, subfamily K, member 4
chr10_-_52315436	0.658	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chr4_+_14950657	0.656	NM_001135170	C1QTNF7	C1q and tumor necrosis factor related protein 7
chr7_-_107230867	0.654	NM_000111	SLC26A3	solute carrier family 26, member 3
chr1_-_108588186	0.653	NM_001143989	NBPF4 NBPF6	neuroblastoma breakpoint family, member 4 neuroblastoma breakpoint family, member 6
chr10_+_123744131	0.646		TACC2	transforming, acidic coiled-coil containing protein 2
chr12_+_102859354	0.645		HSP90B1	heat shock protein 90kDa beta (Grp94), member 1
chrX_+_135210787	0.640	NM_153834	GPR112	G protein-coupled receptor 112
chr17_+_29606408	0.638	NM_002982	CCL2	chemokine (C-C motif) ligand 2
chr3_-_38810504	0.637	NM_006514	SCN10A	sodium channel, voltage-gated, type X, alpha subunit
chr16_+_52081836	0.634		RBL2	retinoblastoma-like 2 (p130)
chr3_+_149930656	0.626	NM_032049	AGTR1	angiotensin II receptor, type 1
chr9_-_21156609	0.625	NM_002175	IFNA21	interferon, alpha 21
chr1_-_93172119	0.622
chrX_+_70255128	0.621	NM_005120	MED12	mediator complex subunit 12
chr11_+_113280727	0.609	NM_006028	HTR3B	5-hydroxytryptamine (serotonin) receptor 3B
chr3_+_12367993	0.608	NM_015869	PPARG	peroxisome proliferator-activated receptor gamma
chr11_-_117552355	0.606		SCN2B	sodium channel, voltage-gated, type II, beta
chr9_+_91409746	0.603	NM_006705	GADD45G	growth arrest and DNA-damage-inducible, gamma
chr14_+_61532293	0.602	NM_031914	SYT16	synaptotagmin XVI
chr8_-_26780665	0.599		ADRA1A	adrenergic, alpha-1A-, receptor
chr14_-_20098929	0.599	NM_001001673 NM_001110356 NM_001110357 NM_001110358 NM_001110359 NM_001110360 NM_001110361	RNASE9	ribonuclease, RNase A family, 9 (non-active)
chr14_-_106149623	0.597
chr3_-_42892195	0.591		CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1
chr2_-_37397669	0.589	NM_005813	PRKD3	protein kinase D3
chr2_-_20390601	0.583	NM_015317	PUM2	pumilio homolog 2 (Drosophila)
chr2_-_215949566	0.582		FN1	fibronectin 1
chr12_-_88573949	0.577	NM_001001323 NM_001682	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1
chr7_+_129057152	0.575	NM_001040110	NRF1	nuclear respiratory factor 1
chr1_-_3556420	0.566	NM_017818	WDR8	WD repeat domain 8
chr11_-_57171554	0.564		YPEL4	yippee-like 4 (Drosophila)
chr1_-_41398126	0.561	NM_001172222	SCMH1	sex comb on midleg homolog 1 (Drosophila)
chr1_+_86785346	0.559	NM_012128	CLCA4	chloride channel accessory 4
chr12_+_54231249	0.557	NM_001005494	OR6C4	olfactory receptor, family 6, subfamily C, member 4
chr1_-_229071957	0.554	NM_001136494	C1orf198	chromosome 1 open reading frame 198
chr15_+_19883745	0.546	NM_001005241	OR4N4	olfactory receptor, family 4, subfamily N, member 4
chr2_-_200038055	0.544	NM_001172517	SATB2	SATB homeobox 2
chr4_+_74493918	0.542		ALB	albumin
chr4_-_165338312	0.539	NM_012403	ANP32C	acidic (leucine-rich) nuclear phosphoprotein 32 family, member C
chr3_+_99370233	0.539	NM_001005515	OR5H15	olfactory receptor, family 5, subfamily H, member 15
chr12_-_100128115	0.533	NM_145913	SLC5A8	solute carrier family 5 (iodide transporter), member 8
chr1_-_175400441	0.528		ASTN1	astrotactin 1
chr4_-_41445693	0.526	NM_003924	PHOX2B	paired-like homeobox 2b
chr12_+_54172413	0.523	NM_001005519	OR6C68	olfactory receptor, family 6, subfamily C, member 68
chrX_+_141941369	0.516	NM_001009613	SPANXN4	SPANX family, member N4
chr6_-_32605898	0.516	NM_002125	HLA-DRB5	major histocompatibility complex, class II, DR beta 5
chr15_+_63701322	0.514	NM_004727	SLC24A1	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr4_-_74307637	0.509		ANKRD17	ankyrin repeat domain 17
chr8_+_142501188	0.508	NM_007079 NM_032611	PTP4A3	protein tyrosine phosphatase type IVA, member 3
chr5_+_140762551	0.507	NM_018921 NM_032089	PCDHGA9	protocadherin gamma subfamily A, 9
chr6_-_89984214	0.505	NM_002042	GABRR1	gamma-aminobutyric acid (GABA) receptor, rho 1
chr8_+_7340777	0.503	NM_001037668 NM_001040705	DEFB107A DEFB107B	defensin, beta 107A defensin, beta 107B
chrX_-_138875342	0.498	NM_001013403	CXorf66	chromosome X open reading frame 66
chr7_-_122126422	0.496	NM_139175	RNF133	ring finger protein 133
chr3_+_99350859	0.493	NM_001005514	OR5H14	olfactory receptor, family 5, subfamily H, member 14
chr12_-_21379098	0.489	NM_021094	SLCO1A2	solute carrier organic anion transporter family, member 1A2
chr1_-_175400573	0.487	NM_004319 NM_207108	ASTN1	astrotactin 1
chr10_-_5436781	0.486	NM_001171864 NM_024803	TUBAL3	tubulin, alpha-like 3
chr3_+_2908920	0.485	NM_175613	CNTN4	contactin 4
chr11_-_35398077	0.484	NM_001195728	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_-_45648608	0.482		SRBD1	S1 RNA binding domain 1
chr4_+_120276386	0.482	NM_016599	MYOZ2	myozenin 2
chr3_-_174341653	0.476	NM_031955	SPATA16	spermatogenesis associated 16
chr10_+_124660206	0.475	NM_001029888	FAM24A	family with sequence similarity 24, member A
chr8_-_7297296	0.473	NM_058206 NM_058207	SPAG11B	sperm associated antigen 11B
chr9_-_21132143	0.469	NM_002177	IFNW1	interferon, omega 1
chr12_+_54106304	0.468	NM_001005183	OR6C76	olfactory receptor, family 6, subfamily C, member 76
chr11_-_102100833	0.467	NM_002424	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)
chr3_-_110155237	0.467	NM_005459	GUCA1C	guanylate cyclase activator 1C
chr2_-_165768798	0.466	NM_001081676 NM_001081677 NM_006922	SCN3A	sodium channel, voltage-gated, type III, alpha subunit
chr18_-_59480082	0.466	NM_006919	SERPINB3 SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 3 serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr2_+_89715037	0.465
chr12_+_47162552	0.464	NM_152319	C12orf54	chromosome 12 open reading frame 54
chr8_+_120148604	0.461	NM_006438	COLEC10	collectin sub-family member 10 (C-type lectin)
chr10_-_7699192	0.459		ITIH5	inter-alpha (globulin) inhibitor H5
chr11_-_57927457	0.454	NM_001005469	OR5B3	olfactory receptor, family 5, subfamily B, member 3
chr4_-_149577404	0.447
chr11_-_58368555	0.445	NM_145016	GLYATL2	glycine-N-acyltransferase-like 2
chr18_+_41448763	0.442	NM_007163	SLC14A2	solute carrier family 14 (urea transporter), member 2
chr3_+_191588354	0.438	NM_006580	CLDN16	claudin 16
chr7_+_45899621	0.438
chr1_+_93072947	0.436		RPL5	ribosomal protein L5
chr1_-_157772420	0.436	NM_001004469	OR10J5	olfactory receptor, family 10, subfamily J, member 5
chr15_+_36014748	0.434	NM_152453	TMCO5A	transmembrane and coiled-coil domains 5A
chr11_+_59804634	0.431	NM_148975	MS4A4A	membrane-spanning 4-domains, subfamily A, member 4
chr10_+_90552466	0.430	NM_001128215	LIPM	lipase, family member M
chr3_-_55489973	0.430		WNT5A	wingless-type MMTV integration site family, member 5A
chr14_-_57030227	0.429	NM_018168	C14orf105	chromosome 14 open reading frame 105
chr6_-_22410993	0.428	NM_001163558	PRL	prolactin
chr13_-_43101608	0.426	NM_001127615	ENOX1	ecto-NOX disulfide-thiol exchanger 1
chr4_-_151993422	0.425
chr10_+_95838801	0.423	NM_001165979	PLCE1	phospholipase C, epsilon 1
chr7_-_16811131	0.423	NM_006408	AGR2	anterior gradient homolog 2 (Xenopus laevis)
chr1_-_161380562	0.422		RGS5	regulator of G-protein signaling 5
chr15_+_38296920	0.421	NM_001128628 NM_001128629	PAK6	p21 protein (Cdc42/Rac)-activated kinase 6
chrX_+_54483565	0.421	NM_058163	TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr22_+_34025267	0.421	NM_001135729	TOM1	target of myb1 (chicken)
chr11_-_19038803	0.414	NM_054030	MRGPRX2	MAS-related GPR, member X2
chr5_-_58331515	0.413	NM_001197223	PDE4D	phosphodiesterase 4D, cAMP-specific
chr11_-_59390518	0.410	NM_001062	TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)
chrX_+_10084984	0.403	NM_001830	CLCN4	chloride channel 4
chr4_-_122304925	0.398	NM_024873	TNIP3	TNFAIP3 interacting protein 3
chr13_+_112746908	0.396		MCF2L	MCF.2 cell line derived transforming sequence-like
chr7_-_100092003	0.396	NM_016188	ACTL6B	actin-like 6B
chr15_-_39151468	0.395		INO80	INO80 homolog (S. cerevisiae)
chr18_+_61568825	0.394		CDH7	cadherin 7, type 2
chr9_-_111230926	0.392	NM_001145371 NM_001145372	PTPN3	protein tyrosine phosphatase, non-receptor type 3
chr6_-_119512035	0.390	NM_001100411	FAM184A	family with sequence similarity 184, member A
chr3_+_131761867	0.388	NM_001102608	COL6A6	collagen, type VI, alpha 6
chr7_+_45899080	0.387		IGFBP1	insulin-like growth factor binding protein 1
chr11_-_16380967	0.386	NM_001145819 NM_017508	SOX6	SRY (sex determining region Y)-box 6

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
35.23	5.65e-05	GO:0001959	regulation of cytokine-mediated signaling pathway
34.67	6.12e-05	GO:0060759	regulation of response to cytokine stimulus
58.23	1.29e-04	GO:0060338	regulation of type I interferon-mediated signaling pathway
28.19	2.49e-03	GO:0060337	type I interferon-mediated signaling pathway
28.19	2.49e-03	GO:0071357	cellular response to type I interferon
27.74	2.66e-03	GO:0034340	response to type I interferon
14.20	5.10e-03	GO:0009615	response to virus
9.28	7.90e-03	GO:0034097	response to cytokine stimulus
12.94	7.97e-03	GO:0045088	regulation of innate immune response
11.89	1.20e-02	GO:0019221	cytokine-mediated signaling pathway
2.05	1.57e-02	GO:0032501	multicellular organismal process
10.73	1.95e-02	GO:0071345	cellular response to cytokine stimulus
6.92	4.03e-02	GO:0051707	response to other organism

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
4.50	2.00e-03	GO:0044421	extracellular region part
4.66	1.11e-02	GO:0005615	extracellular space

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
11.82	2.63e-03	GO:0005126	cytokine receptor binding
10.99	3.72e-03	GO:0005125	cytokine activity